This phone has come with a problem because the edge is on the right side which is easily accessible to righties but lefties? That's not quite comfortable. If a leftie wants to use the phone he has to turn it upside down so that the thumb can easily reach the edge as you can see in the picture above.
Better still a leftie can use the right hand to operate the phone, it's not that hard to use your weak hand to operate a phone.
Concluding this I will say the lefties should endure with it and use the right hand to operate the phone. I don't think Samsung is ready to make a phone that says "For Lefties" or "For Righties".