Philippe Coutinho hit the bar in the main half before Gerard Moreno's header gave city rivals Espanyol the lead halfway as the second progressed.
With just eight minutes left, safeguard Pique headed home substitute Lionel Messi's free-kick.
The draw broadened Barcelona's lead at best of the table to 12 focuses.
Second-set Atletico Madrid confront Valencia at 20:45 (19:45 GMT), while fourth-put Real Madrid, who drew 2-2 with Levante on Saturday, trail Barcelona by 19 focuses.
Arouse, who was booed all through by the home fans, maddened them encourage by raising his finger to his lips to commend his equalizer.
Barcelona beat Espanyol to achieve the Spanish Cup semi-finals a week ago, after which Pique depicted their opponents as "Espanyol de Cornella" in reference to the suburb where they play.
There was little show right on time in substantial rain at the RCDE Stadium, where Espanyol have not beaten Barca in an alliance diversion, until the point when Coutinho twisted a shot from the edge of the crate against the underside of the bar.
The hosts reacted with Leo Baptistao confiscating Andres Iniesta before terminating directly at Marc-Andre ter Stegen, and the Brazilian striker additionally headed over from a Marc Navarro cross.
Barcelona's Luis Suarez twisted a free-kick barely finished, in spite of the fact that Espanyol thought they had scored in the main moment of the second half when the ball had gone out before Baptistao curtailed for Esteban Granero to change over.
Messi entered the 59th moment however after seven minutes Baptistao won the ball in midfield and Sergio Garcia whipped a great conservative cross into the case, where Moreno got behind Pique to head home his twelfth objective of the season.
In any case, from Messi's free-kick profound on the left wing, Pique scored to take Barca past the 21-amusement unbeaten run set by Pep Guardiola's side in 2009-10.
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